Recheck coagulation status after 20 – 30 minutes and at 4–6 hours and 24 hours (or earlier if clinically indicated).If INR is 1.5–1.9, consideration can be given to administering a small dose of Beriplex ® (e.g.Protamine sulphate – the anticoagulant effects of LMWH are not completely reversed by protamine sulphate, but this drug should be considered if patients are suffering significant haemorrhage following recent (6 Most LMWHs have an elimination half-life of around 2 – 4 hours following subcutaneous injection, although this can be prolonged in renal failure. Subcutaneous low molecular weight heparin (LMWH) Avoid protamine in patients with allergies to fish or fish products. Protamine sulphate 1mg neutralises 100units of heparin.Īdminister protamine up to a maximum of 50mg in a single dose as slow IV infusion over 10 minutes (anaphylaxis has been reported, see the Anaphylaxis guideline for management).
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